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KMID : 0352419940130020146
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Keimyung Medical Journal
1994 Volume.13 No. 2 p.146 ~ p.150
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Isotransplantation of Rat Pancreatic Islet into Portal Vein of Streptozotocin-induce Diabetic Rats*
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박근용
여준기/이인규/강구정/조원현
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Abstract
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We evaluated the functional ability of fresh isolated islet of rats by the methods of collagenase digestion/Ficoll density gradient and we performed isotransplantation of rat islet into portal vein as a first step procedure to islet cell
transplantation.
@ES The results obtained were as follows.
@EN 1) Three out of 10 transplanted rats receiving 250±310 isolated islets normalized their nonfasting morning blood glucose(121±15.5mg/dl) and insulin levels(32.1±5.4uU/ml).
2) Normoglycemia has been maintained for 3 days, 8 days and 14 days in each 3 successfully transplanted rats.
This study suggests that the islet isotransplantation into portal vein by the methods of collagenase digestion and Ficoll denisty gradient is feasible and appropriate method in treating the diabetes and can be used in the human also for the
treatment of
diabetes and could be used in the human diabetes.
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